5-CHLOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER - Names and Identifiers
Name | 5-Chloropyridine-3-boronic acid pinacol ester
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Synonyms | 3-CHLOROPYRIDINE-5-BORONIC ACID PINACOL ESTER 5-Chloropyridine-3-boronic acid pinacol ester 5-CHLOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER 2-(5-Chloro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 3-CHLORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Pyridine, 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
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CAS | 865186-94-3
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InChI | InChI=1/C11H15BClNO2/c1-10(2)11(3,4)16-12(15-10)8-5-9(13)7-14-6-8/h5-7H,1-4H3 |
5-CHLOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER - Physico-chemical Properties
Molecular Formula | C11H15BClNO2
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Molar Mass | 239.51 |
Density | 1.14g/cm3 |
Melting Point | 79-81℃ |
Boling Point | 327.5°C at 760 mmHg |
Flash Point | 151.9°C |
Vapor Presure | 0.000384mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Light yellow |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.505 |
MDL | MFCD06798284 |
5-CHLOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER - Introduction
5-Chloropyridine-3-boronic acid pinacol ester(5-Chloropyridine-3-boronic acid pinacol ester) is an organic compound whose chemical formula is C10H12BClNO2. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 5-Chloropyridine-3-boronic acid pinacol ester is a solid, often in the form of white to light yellow crystals.
-Solubility: This compound is soluble in common organic solvents such as dimethylformamide (DMF), dichloromethane (DCM) and dimethylsulfide (DME).
-Melting point: 5-Chloropyridine-3-boronic acid pinacol ester has a relatively high melting point.
Use:
- 5-Chloropyridine-3-boronic acid pinacol ester is a commonly used reagent in organic synthesis. It can be used as a reducing reagent for sodium benzene sulfonate or sodium hydroxide to synthesize various organic compounds.
-The compound can also be used as a ligand, used in conjunction with a palladium catalyst in the coupling reaction, and used to construct aromatic compounds and heterocyclic structures.
Preparation Method:
- 5-Chloropyridine-3-boronic acid pinacol ester can be prepared by the esterification reaction between 5-chloropyridine and sodium triborane and tridiol.
Safety Information:
-Due to the absence of specific safety reports or studies, there is limited specific safety information regarding this compound. However, as chemical agents, users should follow the laboratory's safe practices and properly wear appropriate personal protective equipment, such as lab gloves and goggles, to avoid contact with skin and eyes.
-Need to be handled and stored carefully, avoid contact with strong oxidants and combustibles, and use in a well-ventilated place.
Please note that for specific uses and safety information on chemicals, it is best to consult and follow relevant official literature and laboratory guidance prior to use.
Last Update:2024-04-10 22:29:15